Polyphenylene carboxymethylene (PPCM) is a polymer derived from mandelic acid. PPCM polymer has been extensively evaluated by several major laboratories and is a promising candidate for inhibiting sexually transmitted infections (STIs), contraception, and potentially airborne viral infections. PPCM will be used in topical applications as a vaginal gel.
Preclinical – Advanced (Pre2)
Delivery Route & Method:
Topical - Gel-Vaginal
Mechanism of Action:
PPCM prevents viral binding and fusion to a host cell by attaching to and blocking key viral binding sites. It has been demonstrated that PPCM binds gB on HSV-2 and gp120 on HIV. PPCM has also shown promise against Ebola virus in vitro and gonorrhea, in vitro and in mice. PPCM renders sperm infertile without damaging other cells.
- Yaso Therapeutics
- Nat. Institute Child Health & Human Development (NICHD)
Phase 2B SBIR
- Polyphenylene Carboxymethylene (PPCM)