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Polyphenylene carboxymethylene (PPCM) is a polymer derived from mandelic acid. PPCM polymer has been extensively evaluated by several major laboratories and is a promising candidate for inhibiting sexually transmitted infections (STIs), contraception, and potentially airborne viral infections. PPCM will be used in topical applications as a vaginal gel.

Development Stage:

Clinical – Phase 0 Trial (C0)



Delivery Route & Method:

Topical - Gel-Vaginal

Mechanism of Action:

PPCM prevents viral binding and fusion to a host cell by attaching to and blocking key viral binding sites. It has been demonstrated that PPCM binds gB on HSV-2 and gp120 on HIV. PPCM has also shown promise against Ebola virus in vitro and gonorrhea, in vitro and in mice. PPCM renders sperm infertile without damaging other cells.


  • Yaso Therapeutics


  • Nat. Institute Child Health & Human Development (NICHD)

Funding Mechanism:

Phase 2B SBIR

Past Funding:


Active Ingredient(s):

  • Polyphenylene Carboxymethylene (PPCM)

Product Indication(s):

  • Gonorrhea
  • HSV-2
  • Pregnancy

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