PPCM Gel
Polyphenylene carboxymethylene (PPCM) is a polymer derived from mandelic acid. PPCM polymer has been extensively evaluated by several major laboratories and is a promising candidate for inhibiting sexually transmitted infections (STIs), contraception, and potentially airborne viral infections. PPCM will be used in topical applications as a vaginal gel.
Development Stage:
Clinical – Phase 1 Trial (C1)
Hormonal/Non-Hormonal:
Non-Hormonal
Delivery Route & Method:
Topical - Gel-Vaginal
Mechanism of Action:
PPCM prevents viral binding and fusion to a host cell by attaching to and blocking key viral binding sites. It has been demonstrated that PPCM binds gB on HSV-2 and gp120 on HIV. PPCM has also shown promise against Ebola virus in vitro and gonorrhea, in vitro and in mice. PPCM renders sperm infertile without damaging other cells.
Developer:
- Yaso Therapeutics
Funding:
Funding Mechanism:
Fast Track SBIR grant
Past Funding:
NIH: SBIR
Active Ingredient(s):
- Polyphenylene Carboxymethylene (PPCM)
Product Indication(s):
- Gonorrhea
- HSV-2
- Unintended Pregnancy