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Non-hormonal Contraceptive Multipurpose Prevention Technology (MPT) Containing Q-Griffithsin (QGRFT)

The Population Council is developing a self-administered, non-hormonal contraceptive fast-dissolving insert for on-demand prevention of pregnancy, HIV, and other sexually transmitted infections. Additional benefits may include the prevention of bacterial vaginosis.

Development Stage:

Preclinical – Early (Pre1)

Hormonal/Non-Hormonal:

Non-Hormonal

Delivery Route & Method:

Topical - Fast Dissolving Insert/Capsule-Vaginal

Mechanism of Action:

The selected organic acids will lower vaginal pH (pH = 3.5-4.5) in the presence of semen. The low pH inactivates sperm and bacteria. When inserted into the vagina, the FDI dissolves into a viscous gel delivering the active agents throughout the vaginal lumen to prevent sperm penetration. QGRFT is a potent non-antiretroviral (ARV) inhibitor of HIV. QGRFT binds to HIV envelope glycoproteins and prevents entry of HIV into target cells.

Developer:

  • Population Council

Funding:

  • Nat. Institute Allergy & Infect. Diseases (NIAID)
  • National Institutes of Health (NIH)
  • Population Council

Funding Mechanism:

NIH: R01 (NIAID)

Active Ingredient(s):

  • QGRFT
  • Organic acids

Product Indication(s):

  • Bacterial Vaginosis (BV)
  • Chlamydia
  • Gonorrhea
  • HIV
  • HSV-2
  • Pregnancy

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