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Dapivirine + Levonorgestrel IVR

The ring is made of a flexible polymer and contains dapivirine, an ARV, and levonorgestrel, a contraceptive hormone, both of which are slowly released over the course of three months. Women would insert the ring into the vagina themselves and replace it every three months.

Development Stage:

Clinical – Phase 1 Trial (C1)



Delivery Route & Method:

Intravaginal - Intravaginal Ring (IVR)

Mechanism of Action:

non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), Progestin


  • International Partnership for Microbicides (IPM)


  • Ministry of Foreign Affairs of Denmark
  • UK Government’s Foreign, Commonwealth & Development Office (FCDO)
  • Ministry of Foreign Affairs of the Netherlands
  • Irish Aid
  • PEPFAR through USAID
  • U.S. Agency for International Development (USAID)

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