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Dapivirine + Levonorgestrel IVR

Silicone, matrix ring. For 90 days. One C1 trial completed; second C1 trial began in 2018.

Development Stage:

Clinical – Phase 1 Trial (C1)

Hormonal/Non-Hormonal:

Hormonal

Delivery Route & Method:

Topical - Intravaginal Ring (IVR)

Mechanism of Action:

non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), Progestin

Developer:

  • International Partnership for Microbicides (IPM)

Funding:

  • Danish Ministry of Foreign Affairs
  • DFID
  • Dutch Ministry of Foreign Affairs
  • Irish Aid
  • OGAC/PEPFAR
  • U.S. Agency for International Development (USAID)

Funding Mechanism:

USAID: Cooperative Agreement

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