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Tenofovir + Levonorgestrel IVR

Polyurethane, dual-reservoir ring designed for 3 months of continuous use, or with up to 3 days intermittent removal. The first-in-women Phase I trial (CONRAD-128) completed in 2016 and successfully met all performance benchmarks. An expanded Phase I study (CONRAD-138) was completed in 2019. A first-in-kind study to evaluate MPT IVRs in Africa, the CDC Kisumu Combined Ring Study (CONRAD B17-144) was also completed in late 2019.

Development Stage:

Clinical – Phase 2 Trial (C2)



Delivery Route & Method:

Intravaginal - Intravaginal Ring (IVR)

Mechanism of Action:

nucleoside analogue reverse transcriptase inhibitor (NRTI), progestin




  • Centers for Disease Control and Prevention (CDC)
  • U.S. Agency for International Development (USAID)

Funding Mechanism:

USAID: Cooperative Agreement

Past Funding:

Bill & Melinda Gates Foundation
NIH: Interagency Agreements to USAID

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