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MIV-150 and zinc acetate in carrageenan gel (PC-1005)

PC-1005 is a topical gel designed for on-demand use both vaginally and rectally to prevent HIV, HSV-2 and HPV. Phase 1 vaginal and rectal trials have been completed with no safety concerns.

Development Stage:

Clinical – Phase 2 Trial (C2)



Delivery Route & Method:

Topical - Gel-Vaginal;Rectal

Mechanism of Action:

non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), entry inhibitor


  • Population Council


  • National Institutes of Health (NIH)

Funding Mechanism:

NIH: Microbicide Trials Network (MTN-037)

Past Funding:

USAID: Cooperative Agreement

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