MIV-150 and zinc acetate in carrageenan gel (PC-1005)
PC-1005 is a topical gel designed for on-demand use both vaginally and rectally to prevent HIV, HSV-2 and HPV. Phase 1 vaginal and rectal trials have been completed with no safety concerns.
Development Stage:
Clinical – Phase 2 Trial (C2)
Hormonal/Non-Hormonal:
Non-Contraceptive
Delivery Route & Method:
Topical - Gel-Vaginal;Rectal
Mechanism of Action:
non-nucleoside analogue reverse transcriptase inhibitor (NNRTI), entry inhibitor
Developer:
- Population Council
Funding:
- National Institutes of Health (NIH)
Funding Mechanism:
NIH: Microbicide Trials Network (MTN-037)
Past Funding:
USAID: Cooperative Agreement
Active Ingredient(s):
- Carrageenan
- MIV-150
- Zinc
Product Indication(s):
- HIV
- HPV
- HSV-2
Useful Links:
- http://www.popcouncil.org/research/developing-arv-based-microbicide-and-microbicide-contraceptive-vaginal-ring
- http://www.popcouncil.org/news/population-council-launches-phase-1-clinical-trial-of-a-novel-microbicide-g
- http://www.mtnstopshiv.org/studies/7224
- https://clinicaltrials.gov/ct2/show/NCT02033109?term=PC-1005&rank=1
- https://clinicaltrials.gov/ct2/show/NCT03408899?term=PC-1005&draw=2&rank=1