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Amphora fast-dissolving vaginal insert (FDI)

An on-demand fast dissolve vaginal insert (FDI) MPT vaginal pH regulator (MVP-R™) for pregnancy and STI prevention.

Development Stage:

Preclinical – Early (Pre1)

Hormonal/Non-Hormonal:

Non-Hormonal

Delivery Route & Method:

Topical - Fast Dissolving Insert/Capsule-Vaginal

Mechanism of Action:

Amphora lowers vaginal pH (pH = 3.5-4.5) in the presence of semen. The low pH inactivates sperm and bacteria. Gel coats vaginal and cervical mucosa and prevents sperm penetration.

Developer:

  • Evofem Biosciences, Inc.
  • Population Council

Funding:

  • Nat. Institute Allergy & Infect. Diseases (NIAID)
  • National Institutes of Health (NIH)

Funding Mechanism:

NIH: R01 (NIAID)

Active Ingredient(s):

  • Citric Acid
  • L-lactic Acid
  • Potassium Bitartrate

Product Indication(s):

  • Bacterial Vaginosis (BV)
  • Chlamydia
  • Gonorrhea
  • Pregnancy

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