Amphora fast-dissolving vaginal insert (FDI)
An on-demand fast dissolve vaginal insert (FDI) MPT vaginal pH regulator (MVP-R™) for pregnancy and STI prevention.
Development Stage:
Preclinical – Early (Pre1)
Hormonal/Non-Hormonal:
Non-Hormonal
Delivery Route & Method:
Topical - Fast Dissolving Insert/Capsule-Vaginal
Mechanism of Action:
Amphora lowers vaginal pH (pH = 3.5-4.5) in the presence of semen. The low pH inactivates sperm and bacteria. Gel coats vaginal and cervical mucosa and prevents sperm penetration.
Developer:
- Evofem Biosciences, Inc.
- Population Council
Funding:
- Nat. Institute Allergy & Infect. Diseases (NIAID)
- National Institutes of Health (NIH)
Funding Mechanism:
NIH: R01 (NIAID)
Active Ingredient(s):
- Citric Acid
- L-lactic Acid
- Potassium Bitartrate
Product Indication(s):
- Bacterial Vaginosis (BV)
- Chlamydia
- Gonorrhea
- Pregnancy