Amphora/QGriffithsin (QGRFT) fast-dissolving vaginal insert (FDI)
Multipurpose Vaginal pH Regulator (MVP-R™) with non-ARV (anti-retroviral) microbicide for the prevention of pregnancy and HIV.
Preclinical – Early (Pre1)
Delivery Route & Method:
Topical - Fast Dissolving Insert/Capsule-Vaginal
Mechanism of Action:
Amphora lowers vaginal pH (pH = 3.5-4.5) in the presence of semen. The low pH inactivates sperm and bacteria. Gel coats vaginal and cervical mucosa and prevents sperm penetration. QGRFT is a potent non-ARV inhibitor of HIV. QGRFT binds to HIV envelope glycoproteins and prevents entry of HIV into target cells.
- Evofem Biosciences, Inc.
- Population Council
- Nat. Institute Allergy & Infect. Diseases (NIAID)
- National Institutes of Health (NIH)
NIH: R01 (NIAID)
- Citric Acid
- L-lactic Acid
- Potassium Bitartrate
- QGriffithsin (QGRFT)
- Bacterial Vaginosis (BV)