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Amphora/QGriffithsin (QGRFT) fast-dissolving vaginal insert (FDI)

Multipurpose Vaginal pH Regulator (MVP-R™) with non-ARV (anti-retroviral) microbicide for the prevention of pregnancy and HIV.

Development Stage:

Preclinical – Early (Pre1)



Delivery Route & Method:

Topical - Fast Dissolving Insert/Capsule-Vaginal

Mechanism of Action:

Amphora lowers vaginal pH (pH = 3.5-4.5) in the presence of semen. The low pH inactivates sperm and bacteria. Gel coats vaginal and cervical mucosa and prevents sperm penetration. QGRFT is a potent non-ARV inhibitor of HIV. QGRFT binds to HIV envelope glycoproteins and prevents entry of HIV into target cells.


  • Evofem Biosciences, Inc.
  • Population Council


  • Nat. Institute Allergy & Infect. Diseases (NIAID)
  • National Institutes of Health (NIH)

Funding Mechanism:


Active Ingredient(s):

  • Citric Acid
  • L-lactic Acid
  • Potassium Bitartrate
  • QGriffithsin (QGRFT)

Product Indication(s):

  • Bacterial Vaginosis (BV)
  • Chlamydia
  • Gonorrhea
  • HIV
  • Pregnancy

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