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Description: Solid, tablet-like dosage form for dual-compartment (vaginal or rectal) on-demand use. A Phase I study to assess safety, pharmacokinetics, and pharmacodynamics of the TAF/EVG insert administered vaginally (CONRAD A18-146) was completed in Q1 of 2019; data are expected by Q3 of 2019. A Phase 1 study to assess rectal administration of the insert (MTN-039) is pending initiation in early Q3 2019. A placebo form of this insert is also being evaluated in an international, multi-site acceptability study (MTN-035, DESIRE) comparing three different rectal dosage forms.
This project is made possible by the generous support of the American people through the United States Agency for International Development (USAID) under the terms of Cooperative Agreement #AID-OAA-A-16-00045. The contents are the responsibility of the IMPT, CAMI Health, PHI, and its partners and do not necessarily reflect the views of USAID or the U.S. Government.