MPT Product Development Database

This database includes MPT products that are currently available, as well as MPT products in active development. The database outlines detailed product information and can be searched to display products by desired criteria as selected from the drop-down boxes or by entering a keyword in the search box. Click on the product name to access detailed information on each product. Click here to learn more about the inclusion criteria and information update methodology.
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Click on the table for MPT products in the development pipeline by indication combination.
Hormonal/Non-HormonalDelivery RouteDelivery MethodDevelopment Stage
IndicationProduct DeveloperProduct Sponsor/FundingActive Ingredient
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23 product(s) found

Tenofovir + Levonorgestrel IVR

MPT in Development

Development Stage:
Clinical – Phase 2 Trial (C2)
Delivery Route & Method:
Topical - Intravaginal Ring (IVR)
Mechanism of Action:
nucleoside analogue reverse transcriptase inhibitor (NRTI), progestin
  • Funding:
  • The Bill & Melinda Gates Foundation
  • Centers for Disease Control and Prevention (CDC)
  • National Institutes of Health (NIH)
  • U.S. Agency for International Development (USAID)
  • Funding Mechanism:
    USAID: Cooperative agreement;
    Past Funding:
    Bill & Melinda Gates Foundation,
    NIH (interagency agreements to USAID)
    Active Ingredient:
  • Levonorgestrel
  • Tenofovir (TFV)
  • Product Indications:
  • HIV
  • HSV-2
  • Pregnancy
  • Description:
    Polyurethane, dual-reservoir ring designed for 3 months of continuous use, or with up to 3 days intermittent removal. The first-in-women Phase I trial (CONRAD-128) completed in 2016 and successfully met all performance benchmarks. An expanded Phase I study (CONRAD-138) was completed in early 2019; results expected mid-2020. A first-in-kind study to evaluate MPT IVRs in Africa, the CDC Kisumu Combined Ring Study (CONRAD B17-144) was completed in late 2019; results expected in late 2020.
    IMPT Secretariat
    1750 Howe Avenue, Suite 550
    Sacramento, CA 95825
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    © Copyright 2019, Public Health Institute / CAMI Health / IMPT Secretariat. All rights reserved.

    The Initiative for Multipurpose Prevention Technologies (IMPT) is a project of CAMI Health, an organization dedicated to advancing the comprehensive sexual and reproductive health of women and girls worldwide. CAMI Health is housed at the Public Health Institute (PHI).

    This project is made possible by the generous support of the American people through the United States Agency for International Development (USAID) under the terms of Cooperative Agreement #AID-OAA-A-16-00045. The contents are the responsibility of the IMPT, CAMI Health, PHI, and its partners and do not necessarily reflect the views of USAID or the U.S. Government.