The study aimed to explore the efficacy and safety of an intravaginal acetic acid thermoreversible gel in Chinese women of reproductive age, comparing it with nonoxinol gel by assessing the six-month Pearl Index and the incidence of any side effects.
mAb 2C7 + TDF IVR
mAb 2C7 and TDF will be formulated into IVRs. mAb 2C7 will have activity against gonorrhea and TDF will target HIV.
For more information, contact: John Moss at j.moss@oak-crest.org
Non-Hormonal Electrospun Mesh
Electrospun fibers were fabricated in a stacked architecture by blend electrospinning using polycaprolactone (PCL) as the backing layer for delivering NFP and cellulose acetate phthalate (CAP) as the top layer for delivering TFV. An analysis of surface morphology, mechanical and chemical properties, mucoadhesion, drug release profiles, encapsulation efficiency, and safety assessments was performed.
For more information, contact: Margaret Ilomuanya at milomuanya@unilag.edu.ng
Tenofovir + Levonorgestrel Vaginal Film
A vaginal film loaded with Tenofovir and Levonorgestrel for the prevention of HIV, other STIs and unintended pregnancies. Poly-vinyl-alcohol was employed as a film forming polymer, chitosan was deployed to improve the mucoadhesive properties of the film and polyethylene glycol as a plasticizer.
For more information, contact: Margaret Ilomuanya at milomuanya@unilag.edu.ng
TAF/EVG/Doxycycline Topical Insert
For more information, contact: Meredith Clark at clarkmr@odu.edu / conradinnovations@odu.edu
Monoclonal Antibody ER MPT Film
The aim of this study is to develop and evaluate a monoclonal antibody-based extended-release (ER) multipurpose prevention technology (MPT) vaginal film that provides up to 7 days of protection against unintended pregnancy, HIV, and HSV from a single application.
For more information, contact: Lisa Rohan at lrohan@mwri.magee.edu
Long-acting refillable nanofluidic implant (NanoMPI)- SC
For more information, contact: Alessandro Grattoni at agrattoni@houstonmethodist.org
Griffithsin (GRFT) Fast-Dissolving Insert (FDI)
The Griffithsin (GRFT) fast-dissolving insert (FDI) is developed by Population Council. This fast-dissolving vaginal insert is an on-demand HIV prevention product for women and girls, including pregnant and breastfeeding women, designed for over-the-counter distribution as a non-antiretroviral option. Manufacturable in low- and middle-income countries, the safe, discreet, user-controlled, and portable fast-dissolving insert has activity against HIV, HSV-2, and HPV, and may be suitable for over-the-counter distribution. Building on favorable outcomes in animal models and with a new supply of GRFT in-hand, the GRFT FDI will be advanced through a new program of stability testing.